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Downstream Process Scientist

Downstream Process Scientist

  • Location

    Liverpool

  • Sector:

    Scientific

  • Job type:

    Contract

  • Salary:

    £26 - 32,000 depending on experience

  • Contact:

    Johnathan Miller

  • Contact email:

    Johnathanm@scantec.co.uk

  • Contact phone:

    +44 (0)151 666 8968

  • Job ref:

    SP-SCiEN-081772

  • Published:

    8 months ago

  • Duration:

    12 months initially

  • Expiry date:

    2019-02-25

  • Start date:

    As soon as possible

Downstream Process Scientist
Up to £32,000
12 month contract
Based in Liverpool
Pharmaceutical industry

A multinational Pharmaceutical company based in Liverpool is looking for an additional Process Scientist on a 12 month contract basis within their Downstream Development area.  Experience in development of and operation of, a range of downstream techniques (e.g. chromatography, UF/DF, depth filtration) is particularly important.

Details:

The company has a large pipeline of biosimilar and innovator molecules in various stages of development. In order to support the expanding pipeline they require extra resource across process science. In the roles there will be the potential opportunity to work on both upstream and downstream parts of the process. For the weekend cover this will be predominantly upstream focussed. Due to the nature of the upstream process and the physical growth and maintenance of cells, their processes run across the weekend. They need resource to help increase their capacity and ability to support these processes.   

The company:

The Liverpool site is a state of the art development and clinical manufacturing facility and is one of their centre of excellences for Biologic development. They are responsible for leading all aspects of bulk drug substance development for innovator and biosimilar products throughout their product lifecycle. To achieve this the company characterises their products, develops robust and scalable processes and assess new technologies to ensure that they deliver cost effective, safe products to their patients. They manufacture product in-house to supply clinical trials or collaborate directly with external partners. Their success is underpinned through bold actions, collaboration and scientific excellence.

Downstream Process Scientist Duties:
  • The successful Scientist in Process Science will perform a wide range of activities associated with the design, development, scale-up, technical transfer and cGMP clinical manufacture of bulk drug substances expressed from both mammalian and microbial expression systems.
  • The role is laboratory/pilot plant based and encompasses example activities including: mammalian cell line development, process optimization and use of high throughput techniques, process scale-up, inoculum culture preparation and operation of bioreactors, purification operations such as chromatography and filtration.
Qualifications and Experience
  • Minimum qualification of BSc (or equivalent). Ideally holding a PhD and/or have relevant industrial experience within the field of bioprocess development, scale-up or cGMP manufacturing.
  • Knowledge and previous experience of mammalian and microbial based processes – this can be from University or from a PhD as training will be provided in the industrial use of mammalian and microbial cell culturing.
  • The successful applicant should have the ability to interpret scientific data and effectively communicate and report findings generated.
  • Experience in design of experiments to deliver robust and effective experimental plans is advantageous
  • Applicants are expected to have relevant industry experience and technical process development skills.
  • Experience in development of and operation of, a range of downstream techniques (e.g. chromatography, UF/DF, depth filtration).
  • In addition ideally have GMP experience, and experience of working with gene therapy products.
For further details and to apply please contact Johnathan Miller at Scantec on 0151._ 666._ 8925 and johnathanm (at) scantec. co. uk




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